Passing down maternal dietary memories through lncRNAs

Xin Yi Koh; Jun Wei Pek

doi:10.1016/j.tig.2022.07.006

Passing down maternal dietary memories through lncRNAs

Trends Genet. 2023 Feb;39(2):91-93. doi: 10.1016/j.tig.2022.07.006. Epub 2022 Aug 4.

Authors

Xin Yi Koh¹, Jun Wei Pek²

Affiliations

¹ Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, Singapore 117604, Singapore.
² Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, Singapore 117604, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive, Singapore 117543, Singapore. Electronic address: junwei@tll.org.sg.

PMID: 35934591
DOI: 10.1016/j.tig.2022.07.006

Abstract

Parental diet is known to influence the offspring in an intergenerational manner, and this has been implicated in species adaptation and general health. Recent studies highlight the role of maternal long noncoding RNAs (lncRNAs) in serving as one of the 'memories' of maternal diet in regulating offspring development and predisposition to metabolic disease.

Keywords: diet; intergenerational inheritance; long noncoding RNA; maternal; oocyte.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diet
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding