Survival and neurologic outcome of infants with medulloblastoma treated with surgery and MOPP chemotherapy. A preliminary report

Cancer. 1987 Jul 15;60(2):173-7. doi: 10.1002/1097-0142(19870715)60:2<173::aid-cncr2820600209>3.0.co;2-f.

Abstract

The results of treatment of infants with medulloblastoma using surgery and chemotherapy, without the use of radiation therapy, are reported. Both survival and outcome, in terms of growth, neurologic deficit, and intelligence are compared with the same parameters in children treated conventionally. Although preliminary, our results suggest that chemotherapy combined with surgery is a valid option for the treatment of infants with this type of neoplasm.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cerebellar Neoplasms / drug therapy*
  • Cerebellar Neoplasms / mortality
  • Cerebellar Neoplasms / surgery
  • Child, Preschool
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Mechlorethamine / administration & dosage
  • Medulloblastoma / drug therapy*
  • Medulloblastoma / mortality
  • Medulloblastoma / surgery
  • Neurologic Examination
  • Prednisone / administration & dosage
  • Procarbazine / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Prednisone

Supplementary concepts

  • MOPP protocol