Come on mtDNA, light my fire

Grace M E P Lawrence; Caroline L Holley; Kate Schroder

doi:10.1016/j.immuni.2022.07.011

Come on mtDNA, light my fire

Immunity. 2022 Aug 9;55(8):1331-1333. doi: 10.1016/j.immuni.2022.07.011.

Authors

Grace M E P Lawrence¹, Caroline L Holley¹, Kate Schroder²

Affiliations

¹ Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, QLD, Australia.
² Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, QLD, Australia. Electronic address: k.schroder@imb.uq.edu.au.

PMID: 35947975
DOI: 10.1016/j.immuni.2022.07.011

Abstract

Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, igniting NLRP3 and cGAS-STING signaling and inflammation.

Publication types

Comment

MeSH terms

DNA, Mitochondrial* / genetics
Inflammasomes
Mitochondria / genetics
NLR Family, Pyrin Domain-Containing 3 Protein*
Signal Transduction

Substances

DNA, Mitochondrial
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein