A new perspective of hypothalamic disease: Shapiro's syndrome

Linan Ren; Xiaokun Gang; Shuo Yang; Meixin Sun; Guixia Wang

doi:10.3389/fneur.2022.911332

A new perspective of hypothalamic disease: Shapiro's syndrome

Front Neurol. 2022 Jul 29:13:911332. doi: 10.3389/fneur.2022.911332. eCollection 2022.

Authors

Linan Ren¹, Xiaokun Gang¹, Shuo Yang², Meixin Sun¹, Guixia Wang¹

Affiliations

¹ Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.
² Department of Clinical Nutrition, The First Hospital of Jilin University, Changchun, China.

Abstract

Shapiro's syndrome (SS) is characterized by spontaneous periodic hypothermia. It occurs to patients regardless of age or sex. To date, <60 cases have been reported worldwide. Current knowledge of the disease is limited to clinical feature since the pathogenesis and etiology are still controversial. In this review, the clinical characteristics, pathological mechanism, and possible etiology of the syndrome were reviewed to improve the clinical understanding of the disease.

Keywords: Shapiro's syndrome; agenesis of the corpus callosum; hyperhidrosis; hypothalamic dysfunctional; hypothermia.

Publication types

Review