The activity of cytokines in dental pulp

Li Yan; Liu Lihua; Zhang Sha; Wu Hongli; Zhong Wu; Tian Guijun; Zhang Kai; Luo Yahui

doi:10.1002/jgm.3444

The activity of cytokines in dental pulp

J Gene Med. 2022 Sep;24(9):e3444. doi: 10.1002/jgm.3444. Epub 2022 Sep 7.

Authors

Li Yan¹, Liu Lihua², Zhang Sha¹, Wu Hongli¹, Zhong Wu¹, Tian Guijun¹, Zhang Kai¹, Luo Yahui¹

Affiliations

¹ Department of Stomatology, Jingshan People's Hospita, Jingshan, China.
² Hanyang Outpatient Clinic, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

PMID: 35999039
DOI: 10.1002/jgm.3444

Abstract

Background: After binding to their corresponding receptors, cytokines mediate a variety of biological activities. However, the activity of cytokines in dental pulp has not been studied at the single cell level.

Methods: The cytokines activity of dental pulp was analyzed through CytoSig with the single cell sequencing data of dental pulp.

Results: In total, 43 cytokine signalling pathways were analyzed with CytoSig. The activity of TRAIL, NO, IL3, CXCL12 and IL1A was high in the majority of cells in dental pulp. NO, TRAIL, CXCL12, BMP4 and BMP6 had higher activity in dental pulp stem cells, whereas CXCL12, BMP4, BMP6, BMP2 and IFN1 were the cytokines with high activity in pulp cells.

Conclusions: Our findings show the landscape of cytokine activity in dental pulp.

Keywords: cytokines; dental pulp; single cell sequencing.

MeSH terms

Cells, Cultured
Cytokines* / metabolism
Dental Pulp*
Receptors, Cytokine
Signal Transduction

Substances

Cytokines
Receptors, Cytokine