Th2A cells: The pathogenic players in allergic diseases

Ziyu Huang; Ming Chu; Xi Chen; Ziyuan Wang; Lin Jiang; Yinchao Ma; Yuedan Wang

doi:10.3389/fimmu.2022.916778

Th2A cells: The pathogenic players in allergic diseases

Front Immunol. 2022 Aug 8:13:916778. doi: 10.3389/fimmu.2022.916778. eCollection 2022.

Authors

Ziyu Huang^{1

2}, Ming Chu¹, Xi Chen¹, Ziyuan Wang¹, Lin Jiang¹, Yinchao Ma¹, Yuedan Wang¹

Affiliations

¹ Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
² Department of Clinical Medicine, Mudanjiang Medical University, Mudanjiang, China.

Abstract

Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3⁺ CD4⁺ HPGDS⁺ CRTH2⁺ CD161^high ST2^high CD49d^high CD27^low play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.

Keywords: CD161; CRTH2; HPGDS; ST2; Th2A cells; allergen-specific Th2 cells; allergic disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Allergens
Dermatitis, Atopic*
Eosinophilic Esophagitis*
Food Hypersensitivity*
Humans
Rhinitis, Allergic*

Substances

Allergens