The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells

Cancer Res. 2022 Nov 15;82(22):4179-4190. doi: 10.1158/0008-5472.CAN-22-1369.

Abstract

This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Colorectal Neoplasms* / genetics
  • Colorectal Neoplasms* / metabolism
  • Cyclic AMP Response Element-Binding Protein / genetics
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Cyclic AMP-Dependent Protein Kinases / genetics
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Humans
  • Neoplasm Metastasis / genetics
  • Neoplasm Metastasis / physiopathology
  • Neoplastic Stem Cells* / metabolism
  • Signal Transduction
  • Smad4 Protein / genetics
  • Smad4 Protein / metabolism
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism

Substances

  • Cyclic AMP Response Element-Binding Protein
  • Cyclic AMP-Dependent Protein Kinases
  • Smad4 Protein
  • SMAD4 protein, human
  • Transforming Growth Factor beta
  • CREB1 protein, human