Comprehensive cancer services include provision of care to patients with advanced hematologic malignancies, among whom some patients are candidates for hematopoietic cell transplantation (HCT). HCT is a complex and resource-intense medical procedure and optimal transplant outcomes require a high-functioning, multidisciplinary, and cohesive team. The presence of a successful HCT program reflects the commitment from a cancer center to provide comprehensive cancer care services. The program can also serve as a platform for performing cellular therapy procedures such as chimeric antigen receptor T-cell therapies. This chapter reviews the potential pathways to establish an HCT and cellular therapy program along with recommendations on the required infrastructure and personnel. In addition, the chapter provides the foundation for establishing a robust quality program and the resources required for data and research.
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