Lassa fever is a viral hemorrhagic fever treated with supportive care and the broad-spectrum antiviral drug ribavirin. The pathophysiology, especially the role of hyperinflammation, of this disease is unknown. We report successful remission of complicated Lassa fever in 2 patients in Nigeria who received the antiinflammatory agent dexamethasone and standard ribavirin.
Keywords: Lassa fever; Lassa mammarenavirus; Lassa virus; Nigeria; concomitant infections; dexamethasone; ribavirin; viral hemorrhagic fever; viruses.