In this paper, a chiral excitation method based on the asymmetric interface condition is proposed. The chiral characteristics of the metamaterials are affected by the difference in the environmental parameters of the front and rear surfaces. Thus, the device can achieve functional reconfiguration and two applications based on this mechanism are presented, one for sensing and the other for chiral switching. At the same time, a self-calibration measurement method that greatly simplifies the sensing system is proposed. These results have potential applications in the fields of chirality excitation, bio-sensing, and reconfigurable device.