The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes

Tomohiro Torii; Tomohiro Miyasaka; Hiroaki Misonou

doi:10.3389/fcell.2022.950682

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes

Front Cell Dev Biol. 2022 Oct 5:10:950682. doi: 10.3389/fcell.2022.950682. eCollection 2022.

Authors

Tomohiro Torii^{1

2}, Tomohiro Miyasaka^{3

2}, Hiroaki Misonou^{1

2}

Affiliations

¹ Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, Japan.
² Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, Japan.
³ Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.

Abstract

Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of tau are dramatical changed in hypomyelination model rat and in demyelination region of stroke model mice. The review demonstrate microtubule and its binding partner Tau might be necessary for oligodendrocyte function based on previous reports.

Keywords: demyelination; myelin; myelination; oligodendrocyte; tau.

Publication types

Review