Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan

Lingjun Zhao; Jing Zhao; Zhihao Dong; Shiyuan Xu; Dong Wang

doi:10.1016/j.reprotox.2022.11.002

Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan

Reprod Toxicol. 2023 Jan:115:1-7. doi: 10.1016/j.reprotox.2022.11.002. Epub 2022 Nov 11.

Authors

Lingjun Zhao¹, Jing Zhao², Zhihao Dong³, Shiyuan Xu¹, Dong Wang⁴

Affiliations

¹ College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China.
² College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China. Electronic address: jlndzjing@126.com.
³ Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471203, China.
⁴ Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: dwangcn2002@vip.sina.com.

PMID: 36372306
DOI: 10.1016/j.reprotox.2022.11.002

Abstract

Busulfan is an alkylating agent commonly used in cancer chemotherapy. It is also an ideal agent for preparing transplant recipients of spermatogonial stem cells because of its high efficiency in destroying endogenous germ cells in the testis. However, its toxicity mechanism remains unclear, affecting its clinical use and applications. Based on reports of busulfan causing orchitis and a previous study by our team, this article summarizes the relationship between busulfan and orchitis, cytokines, the blood-testis barrier, and the cytoskeleton, unravels the regulatory pathways and mechanism behind busulfan-induced orchitis, and reveals the molecular mechanism underlying impaired spermatogenic function in orchitis, providing new ideas for the clinical application of busulfan while reducing its testicular toxicity.

Keywords: Busulfan; Cytokines; Cytoskeleton; Orchitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Busulfan / toxicity
Humans
Infertility, Male* / metabolism
Male
Orchitis* / chemically induced
Orchitis* / metabolism
Spermatogonia
Testis

Substances

Busulfan