Uncovering the degrader of D-type cyclins

Science. 2022 Nov 25;378(6622):845. doi: 10.1126/science.adf4868. Epub 2022 Nov 24.

Author

Daniele Simoneschi¹

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, Grossman School of Medicine, New York University, New York, NY, USA.

PMID: 36423267
DOI: 10.1126/science.adf4868

Abstract

AMBRA1 is identified as the long-sought, major controller of D-type cyclins.

MeSH terms

Adaptor Proteins, Signal Transducing* / metabolism
Carcinogenesis* / metabolism
Cyclin D* / metabolism
Proteolysis*
Proto-Oncogene Proteins* / metabolism

Substances

Cyclin D
Proto-Oncogene Proteins
Il17rb protein, mouse
Ambra1 protein, mouse
Adaptor Proteins, Signal Transducing