A large-scale neural network training framework for generalized estimation of single-trial population dynamics

Nat Methods. 2022 Dec;19(12):1572-1577. doi: 10.1038/s41592-022-01675-0. Epub 2022 Nov 28.

Abstract

Achieving state-of-the-art performance with deep neural population dynamics models requires extensive hyperparameter tuning for each dataset. AutoLFADS is a model-tuning framework that automatically produces high-performing autoencoding models on data from a variety of brain areas and tasks, without behavioral or task information. We demonstrate its broad applicability on several rhesus macaque datasets: from motor cortex during free-paced reaching, somatosensory cortex during reaching with perturbations, and dorsomedial frontal cortex during a cognitive timing task.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Macaca mulatta
  • Motor Cortex*
  • Neural Networks, Computer*
  • Population Dynamics
  • Somatosensory Cortex