The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism

Mahdi Ahsan; Léa Garneau; Céline Aguer

doi:10.3389/fphys.2022.1040809

The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism

Front Physiol. 2022 Nov 21:13:1040809. doi: 10.3389/fphys.2022.1040809. eCollection 2022.

Authors

Mahdi Ahsan¹, Léa Garneau^{1

2}, Céline Aguer^{1

2

3

4

5}

Affiliations

¹ Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
² Institut du Savoir Montfort -Recherche, Ottawa, ON, Canada.
³ Department of Physiology, Faculty of Medicine and Health Sciences, McGill University-Campus Outaouais, Gatineau, QC, Canada.
⁴ School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
⁵ Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.

Abstract

Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling.

Keywords: AMPK; cell signalling; glucose metabolism; lipid metabolism; myokines; skeletal muscle.

Publication types

Review