Interfer(on)ing with Zika virus

Alvaro G Alvarado; Harley I Kornblum

doi:10.1016/j.neuron.2022.10.027

Interfer(on)ing with Zika virus

Neuron. 2022 Dec 7;110(23):3853-3854. doi: 10.1016/j.neuron.2022.10.027.

Authors

Alvaro G Alvarado¹, Harley I Kornblum²

Affiliations

¹ The Intellectual and Developmental Disabilities Research Center, The Semel Institute for Neuroscience and Human Behavior, and The Broad Stem Cell Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
² The Intellectual and Developmental Disabilities Research Center, The Semel Institute for Neuroscience and Human Behavior, and The Broad Stem Cell Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: hkornblum@mednet.ucla.edu.

PMID: 36480937
DOI: 10.1016/j.neuron.2022.10.027

Abstract

In this issue of Neuron, Bulstrode et al.¹ demonstrate that glioblastoma slice cultures, unlike neural progenitors, are refractory to Zika virus infection. The anti-infective mechanism is myeloid-lineage cell-secreted interferon beta. These studies have implications for therapeutics in both glioblastoma and Zika virus infections.

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MeSH terms

Humans
Zika Virus Infection*
Zika Virus*