Fluorescent probes for the detection of disease-associated biomarkers

Wei-Tao Dou; Hai-Hao Han; Adam C Sedgwick; Guo-Biao Zhu; Yi Zang; Xin-Rong Yang; Juyoung Yoon; Tony D James; Jia Li; Xiao-Peng He

doi:10.1016/j.scib.2022.01.014

Fluorescent probes for the detection of disease-associated biomarkers

Sci Bull (Beijing). 2022 Apr 30;67(8):853-878. doi: 10.1016/j.scib.2022.01.014. Epub 2022 Jan 17.

Authors

Wei-Tao Dou¹, Hai-Hao Han¹, Adam C Sedgwick², Guo-Biao Zhu¹, Yi Zang³, Xin-Rong Yang⁴, Juyoung Yoon⁵, Tony D James⁶, Jia Li⁷, Xiao-Peng He⁸

Affiliations

¹ Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
² Department of Chemistry, The University of Texas at Austin, Austin, TX 78712-1224, USA.
³ National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
⁴ Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China. Electronic address: yang.xinrong@zs-hospital.sh.cn.
⁵ Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address: jyoon@ewha.ac.kr.
⁶ Department of Chemistry, University of Bath, Bath BA2 7AY, UK; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China. Electronic address: t.d.james@bath.ac.uk.
⁷ National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: jli@simm.ac.cn.
⁸ Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: xphe@ecust.edu.cn.

PMID: 36546238
DOI: 10.1016/j.scib.2022.01.014

Abstract

Fluorescent probes have emerged as indispensable chemical tools to the field of chemical biology and medicine. The ability to detect intracellular species and monitor physiological processes has not only advanced our knowledge in biology but has provided new approaches towards disease diagnosis. In this review, we detail the design criteria and strategies for some recently reported fluorescent probes that can detect a wide range of biologically important species in cells and in vivo. In doing so, we highlight the importance of each biological species and their role in biological systems and for disease progression. We then discuss the current problems and challenges of existing technologies and provide our perspective on the future directions of the research area. Overall, we hope this review will provide inspiration for researchers and prove as useful guide for the development of the next generation of fluorescent probes.

Keywords: Biomarker detection; Chemical biology; Fluorescence imaging; Fluorescent probes.

Publication types

Review

MeSH terms

Biomarkers
Fluorescent Dyes*

Substances

Fluorescent Dyes
Biomarkers