Long noncoding RNAs: glycolysis regulators in gynaecologic cancers

Nengyuan Lv; Siyi Shen; Qianying Chen; Jinyi Tong

doi:10.1186/s12935-023-02849-2

Long noncoding RNAs: glycolysis regulators in gynaecologic cancers

Cancer Cell Int. 2023 Jan 13;23(1):4. doi: 10.1186/s12935-023-02849-2.

Authors

Nengyuan Lv^{1

2}, Siyi Shen^{1

2}, Qianying Chen^{1

2}, Jinyi Tong^{3

4}

Affiliations

¹ Department of the Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, People's Republic of China.
² Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University of Medicine, Hangzhou, 310006, Zhejiang Province, People's Republic of China.
³ Department of the Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, People's Republic of China. tongjinyi252@zju.edu.cn.
⁴ Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University of Medicine, Hangzhou, 310006, Zhejiang Province, People's Republic of China. tongjinyi252@zju.edu.cn.

Abstract

The three most common gynaecologic cancers that seriously threaten female lives and health are ovarian cancer, cervical cancer, and endometrial cancer. Glycolysis plays a vital role in gynaecologic cancers. Several long noncoding RNAs (lncRNAs) are known to function as oncogenic molecules. LncRNAs impact downstream target genes by acting as ceRNAs, guides, scaffolds, decoys, or signalling molecules. However, the role of glycolysis-related lncRNAs in regulating gynaecologic cancers remains poorly understood. In this review, we emphasize the functional roles of many lncRNAs that have been found to promote glycolysis in gynaecologic cancers and discuss reasonable strategies for future research.

Keywords: Glycolysis; Gynecologic cancers; Markers; lncRNAs.

Publication types

Review