Coordinated cancer chaos

Cell. 2023 Jan 19;186(2):235-237. doi: 10.1016/j.cell.2022.12.015.

Abstract

Stochastic processes, such as genetic instability and microenvironment evolution, drive tumor heterogeneity, thereby creating the chaotic appearance of tumors in histopathology. In this issue of Cell, Lin et al. reveal that tumors are surprisingly spatially organized from a molecular to tissue scale, indicating that cancers evolve as autonomously patterned systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / pathology
  • Nonlinear Dynamics*
  • Tumor Microenvironment