Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Xiaoli Zhang; Yiming Ma; Guoqing Lv; Hongying Wang

doi:10.3389/fphar.2023.1095366

Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Front Pharmacol. 2023 Jan 13:14:1095366. doi: 10.3389/fphar.2023.1095366. eCollection 2023.

Authors

Xiaoli Zhang^{1

2

3}, Yiming Ma¹, Guoqing Lv³, Hongying Wang¹

Affiliations

¹ State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, China.
³ Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, China.

Abstract

Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases.

Keywords: cell death; colorectal cancer; ferroptosis; inflammation; inflammatory bowel disease.

Publication types

Review

Grants and funding

This work was supported by funding from the National Nature Science Foundation of China (82203229 and 81970467), The Shenzhen Science and Technology Innovation Commission Project (JCYJ20220531094005012), the opening project of State Key Laboratory of Explosion Science and Technology (Beijing Institute of Technology, KFJJ22-16M), and the Sanming Project of Medicine in Shenzhen (SZSM201612051).