Proceedings from the Albert Charitable Trust Inaugural Workshop on 'Understanding the Acute Effects of Exercise on the Brain'

Jill N Barnes; Jeffrey M Burns; Marcas M Bamman; Sandra A Billinger; Sue C Bodine; Frank W Booth; Patrice Brassard; Tameka A Clemons; Paul J Fadel; Paige C Geiger; Swathi Gujral; Jacob M Haus; Scott E Kanoski; Benjamin F Miller; Jill K Morris; Kristin M S O'Connell; David C Poole; Darleen A Sandoval; J Carson Smith; Russell H Swerdlow; Shawn N Whitehead; Eric D Vidoni; Henriette van Praag

doi:10.3233/BPL-220146

Proceedings from the Albert Charitable Trust Inaugural Workshop on 'Understanding the Acute Effects of Exercise on the Brain'

Brain Plast. 2022 Dec 20;8(2):153-168. doi: 10.3233/BPL-220146. eCollection 2022.

Authors

Jill N Barnes¹, Jeffrey M Burns², Marcas M Bamman³, Sandra A Billinger², Sue C Bodine⁴, Frank W Booth⁵, Patrice Brassard⁶, Tameka A Clemons⁷, Paul J Fadel⁸, Paige C Geiger⁹, Swathi Gujral¹⁰, Jacob M Haus¹¹, Scott E Kanoski¹², Benjamin F Miller¹³, Jill K Morris², Kristin M S O'Connell¹⁴, David C Poole¹⁵, Darleen A Sandoval¹⁶, J Carson Smith¹⁷, Russell H Swerdlow², Shawn N Whitehead¹⁸, Eric D Vidoni², Henriette van Praag¹⁹

Affiliations

¹ Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
² University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
³ UAB Center for Exercise Medicine, University of Alabama, Birmingham, AL, USA.
⁴ Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
⁵ Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA.
⁶ Department of Kinesiology, Faculty of Medicine, Université Laval, and Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec city, QC, Canada.
⁷ Department of Professional and Medical Education, Meharry Medical College, Nashville, TN, USA.
⁸ Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.
⁹ Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
¹⁰ University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA.
¹¹ School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
¹² Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsrife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.
¹³ Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
¹⁴ The Jackson Laboratory, Bar Harbor, ME, USA.
¹⁵ Departments of Kinesiology, Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.
¹⁶ University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
¹⁷ Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, USA.
¹⁸ Vulnerable Brain Laboratory, Department Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, N6A 5C1, Canada.
¹⁹ Stiles-Nicholson Brain Institute, Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter FL, USA.

Abstract

An inaugural workshop supported by "The Leo and Anne Albert Charitable Trust," was held October 4-7, 2019 in Scottsdale, Arizona, to focus on the effects of exercise on the brain and to discuss how physical activity may prevent or delay the onset of aging-related neurodegenerative conditions. The Scientific Program Committee (led by Dr. Jeff Burns) assembled translational, clinical, and basic scientists who research various aspects of the effects of exercise on the body and brain, with the overall goal of gaining a better understanding as to how to delay or prevent neurodegenerative diseases. In particular, research topics included the links between cardiorespiratory fitness, the cerebrovasculature, energy metabolism, peripheral organs, and cognitive function, which are all highly relevant to understanding the effects of acute and chronic exercise on the brain. The Albert Trust workshop participants addressed these and related topics, as well as how other lifestyle interventions, such as diet, affect age-related cognitive decline associated with Alzheimer's and other neurodegenerative diseases. This report provides a synopsis of the presentations and discussions by the participants, and a delineation of the next steps towards advancing our understanding of the effects of exercise on the aging brain.

Keywords: Alzheimer’s Disease; Parkinson’s Disease; blood vessels; cardiorespiratory fitness; cerebrovasculature; cognition; exercise; mitochondria; neurotrophins.

Abstract

Grants and funding