A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans

Uros Topalovic; Sam Barclay; Chenkai Ling; Ahmed Alzuhair; Wenhao Yu; Vahagn Hokhikyan; Hariprasad Chandrakumar; Dejan Rozgic; Wenlong Jiang; Sina Basir-Kazeruni; Sabrina L Maoz; Cory S Inman; Matthias Stangl; Jay Gill; Ausaf Bari; Aria Fallah; Dawn Eliashiv; Nader Pouratian; Itzhak Fried; Nanthia Suthana; Dejan Markovic

doi:10.1038/s41593-023-01260-4

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans

Nat Neurosci. 2023 Mar;26(3):517-527. doi: 10.1038/s41593-023-01260-4. Epub 2023 Feb 20.

Authors

Uros Topalovic^{1

2}, Sam Barclay¹, Chenkai Ling¹, Ahmed Alzuhair³, Wenhao Yu¹, Vahagn Hokhikyan¹, Hariprasad Chandrakumar¹, Dejan Rozgic¹, Wenlong Jiang¹, Sina Basir-Kazeruni¹, Sabrina L Maoz^{4

5}, Cory S Inman⁶, Matthias Stangl², Jay Gill^{2

5}, Ausaf Bari⁷, Aria Fallah⁷, Dawn Eliashiv⁸, Nader Pouratian⁹, Itzhak Fried^{2

7}, Nanthia Suthana^{10

11

12

13}, Dejan Markovic¹⁴

Affiliations

¹ Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
² Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
³ Department of Electrical Engineering, King Saud University, Riyadh, Saudi Arabia.
⁴ Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
⁵ Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁶ Department of Psychology, University of Utah, Salt Lake City, UT, USA.
⁷ Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁸ Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
⁹ Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
¹⁰ Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
¹¹ Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
¹² Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
¹³ Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.
¹⁴ Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA. dejan@ucla.edu.

Abstract

Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans

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