Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Region

Roberta Borges Andrade; Amanda de Nazaré Cohen-Paes; Diana Feio da Veiga Borges Leal; Karla Beatriz Cardias Cereja Pantoja; Laura Patrícia Albarello Gellen; Darlen Cardoso de Carvalho; Tatiane Piedade de Souza; Marianne Rodrigues Fernandes; Paulo Pimentel de Assumpcão; Rommel Mario Rodríguez Burbano; Sidney Emanuel Batista Dos Santos; Ney Pereira Carneiro Dos Santos

doi:10.3390/genes14020453

Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Region

Genes (Basel). 2023 Feb 9;14(2):453. doi: 10.3390/genes14020453.

Authors

Roberta Borges Andrade¹, Amanda de Nazaré Cohen-Paes¹, Diana Feio da Veiga Borges Leal¹, Karla Beatriz Cardias Cereja Pantoja¹, Laura Patrícia Albarello Gellen¹, Darlen Cardoso de Carvalho¹, Tatiane Piedade de Souza¹, Marianne Rodrigues Fernandes¹, Paulo Pimentel de Assumpcão¹, Rommel Mario Rodríguez Burbano^{1

2}, Sidney Emanuel Batista Dos Santos¹, Ney Pereira Carneiro Dos Santos¹

Affiliations

¹ Oncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
² Ophir Loyola Hospital, Molecular Biology Laboratory, Belém 66063-240, Pará, Brazil.

Abstract

Gastric cancer (GC) is the fifth most common type of cancer and the fourth leading cause of cancer death. In Brazil, GC has a high incidence and mortality rates, and it is highly variable by region. The Amazon region has significant rising rates among all Brazil regions. Only very few studies have evaluated the association between genetic variants and the risk of gastric cancer in the Brazilian Amazon population. Therefore, this study aimed to investigate associations between single nucleotide polymorphisms of miRNA processing genes and the risk for GC in this population. Potentially functional single nucleotide polymorphisms from miRNA processing genes were genotyped in 159 cases and 193 healthy controls by QuantStudio Real Time PCR. According to our findings, the genotype GG of the variant rs10739971 presents a lower risk to the development of GC in comparison to the remaining genotypes (p = 0.000016; OR = 0.055; 95% CI = 0.015-0.206). This is the first study to report the association of pri-let-7a-1 rs10739971 with GC in the Brazilian Amazon population, which is a highly mixed population with a unique genetic constitution that is different from other populations that are studied in the vast majority of scientific research.

Keywords: Amazon; cancer predisposition; gastric cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease
Genotype
Humans
MicroRNAs* / genetics
Polymorphism, Single Nucleotide
Stomach Neoplasms* / genetics

Substances

MicroRNAs
mirnlet7 microRNA, human

Grants and funding

This research was funded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), FAPESPA (Fundação Amazônica de Amparo a Estudos e Pesquisas), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and UFPA (Universidade Federal do Pará). These funding agencies played no role in the study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.