The Roles of TRAF3 in Immune Responses

Dis Markers. 2023 Feb 16:2023:7787803. doi: 10.1155/2023/7787803. eCollection 2023.

Abstract

Seven tumor necrosis factor receptor- (TNFR-) associated factors (TRAFs) have been found in mammals, which are primarily involved in the signal translation of the TNFR superfamily, the Toll-like receptor (TLR) family, and the retinoic acid-inducible gene I- (RIG-I-) like receptor (RLR) family. TRAF3 is one of the most diverse members of the TRAF family. It can positively regulate type I interferon production while negatively regulating signaling pathways of classical nuclear factor-κB, nonclassical nuclear factor-κB, and mitogen-activated protein kinase (MAPK). This review summarizes the roles of TRAF3 signaling and the related immune receptors (e.g., TLRs) in several preclinical and clinical diseases and focuses on the roles of TRAF3 in immune responses, the regulatory mechanisms, and its role in disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate
  • Mammals / metabolism
  • Mitogen-Activated Protein Kinases
  • NF-kappa B* / metabolism
  • Signal Transduction
  • TNF Receptor-Associated Factor 3* / genetics
  • TNF Receptor-Associated Factor 3* / metabolism

Substances

  • TNF Receptor-Associated Factor 3
  • NF-kappa B
  • Mitogen-Activated Protein Kinases
  • TRAF3 protein, human