Aquaporins and Neuropathic Pain

Fei-Xiang Wang; Wen-Mei Xu; Chi-Liang Xu; Jiang Li; Jing-Yan Lin

doi:10.31083/j.fbl2802035

Aquaporins and Neuropathic Pain

Front Biosci (Landmark Ed). 2023 Feb 24;28(2):35. doi: 10.31083/j.fbl2802035.

Authors

Fei-Xiang Wang¹, Wen-Mei Xu¹, Chi-Liang Xu¹, Jiang Li¹, Jing-Yan Lin¹

Affiliation

¹ Department of Anesthesiology, The Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, China.

PMID: 36866545
DOI: 10.31083/j.fbl2802035

Abstract

Neuropathic pain is a chronic secondary pain condition resulting from lesions or diseases of the peripheral or central nervous system (CNS). Neuropathic pain is closely related to edema, inflammation, increased neuronal excitability, and central sensitization caused by glutamate accumulation. Aquaporins (AQPs), mainly responsible for the transport and clearance of water and solute, play important roles in developing CNS diseases, especially neuropathic pain. This review focuses on the interaction of AQPs with neuropathic pain, and the potential of AQPs, especially aquaporins 4, as therapeutic targets.

Keywords: aquaporins; glymphatic system; neuropathic pain; review.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aquaporins*
Central Nervous System
Glutamates
Humans
Inflammation
Neuralgia*

Substances

Aquaporins
Glutamates