1 The Big Data Institute and Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK. Electronic address: nwhiffin@well.ox.ac.uk.
This article is based on the address given by the author at the 2022 meeting of the American Society of Human Genetics (ASHG) in Los Angeles, California. The video of the original address can be found at the ASHG website.