The first fluorescent sensor for the detection of closantel in meat

Conghui Zeng; Chao Song; Zhongyong Xu; Tianyi Qin; Taoyuze Lv; Lei Wang; Xiaoqiang Chen; Bin Liu; Xiaojun Peng

doi:10.1016/j.talanta.2023.124413

The first fluorescent sensor for the detection of closantel in meat

Talanta. 2023 Jun 1:258:124413. doi: 10.1016/j.talanta.2023.124413. Epub 2023 Mar 2.

Authors

Conghui Zeng¹, Chao Song¹, Zhongyong Xu¹, Tianyi Qin¹, Taoyuze Lv², Lei Wang¹, Xiaoqiang Chen¹, Bin Liu³, Xiaojun Peng⁴

Affiliations

¹ College of Material Science and Engineering, Guangdong Research Center for Interfacial Engineering of Functional Materials, State Key Laboratory of Fine Chemicals, Shenzhen University, Shenzhen, 518060, China.
² School of Physics, The University of Sydney, Sydney, NSW, 2006, Australia.
³ College of Material Science and Engineering, Guangdong Research Center for Interfacial Engineering of Functional Materials, State Key Laboratory of Fine Chemicals, Shenzhen University, Shenzhen, 518060, China. Electronic address: bliu@szu.edu.cn.
⁴ College of Material Science and Engineering, Guangdong Research Center for Interfacial Engineering of Functional Materials, State Key Laboratory of Fine Chemicals, Shenzhen University, Shenzhen, 518060, China; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.

PMID: 36871517
DOI: 10.1016/j.talanta.2023.124413

Abstract

Closantel is widely used in the management of parasitic infestation in livestock, but is contraindicated in humans due to its high toxic to human retina. Thus, development of a fast and selective method for the detection of closantel residues in animal products is highly needed yet still challenging. In the present study, we report a supramolecular fluorescent sensor for closantel detection through a two-step screening process. The fluorescent sensor can detect closantel with a fast response (<10 s), high sensitivity, and high selectivity. The limit of detection is 0.29 ppm, which is much lower than the maximum residue level set by government. Moreover, the applicability of this sensor has been demonstrated in commercial drugs tablets, injection fluids, and real edible animal products (muscle, kidney, and liver). This work provides the first fluorescence analytical tool for accurate and selective determination of closantel, and may inspire more sensor design for food analysis.

Keywords: Closantel; Fast response; Fluorescent sensors; Food analysis; Supramolecular recognition.

MeSH terms

Animals
Coloring Agents
Humans
Meat* / analysis
Muscles / chemistry
Salicylanilides* / analysis

Substances

closantel
Salicylanilides
Coloring Agents