A genome-wide perspective of the maternal mRNA translation program during oocyte development

Marco Conti; Chisato Kunitomi

doi:10.1016/j.semcdb.2023.03.003

A genome-wide perspective of the maternal mRNA translation program during oocyte development

Semin Cell Dev Biol. 2024 Feb 15;154(Pt B):88-98. doi: 10.1016/j.semcdb.2023.03.003. Epub 2023 Mar 7.

Authors

Marco Conti¹, Chisato Kunitomi²

Affiliations

¹ Center for Reproductive Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA. Electronic address: Marco.Conti@UCSF.edu.
² Center for Reproductive Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA.

PMID: 36894378
DOI: 10.1016/j.semcdb.2023.03.003

Abstract

Transcriptional and post-transcriptional regulations control gene expression in most cells. However, critical transitions during the development of the female gamete relies exclusively on regulation of mRNA translation in the absence of de novo mRNA synthesis. Specific temporal patterns of maternal mRNA translation are essential for the oocyte progression through meiosis, for generation of a haploid gamete ready for fertilization and for embryo development. In this review, we will discuss how mRNAs are translated during oocyte growth and maturation using mostly a genome-wide perspective. This broad view on how translation is regulated reveals multiple divergent translational control mechanisms required to coordinate protein synthesis with progression through the meiotic cell cycle and with development of a totipotent zygote.

Keywords: Gamete development; Oocyte; RNA binding protein; Translation; mRNA.

Publication types

Review

Abstract

Publication types

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