Characteristics, treatment and care of pregnant women living with hepatitis B in England: findings from a national audit

Epidemiol Infect. 2023 Mar 2:151:e50. doi: 10.1017/S0950268823000225.

Abstract

Around 0.4% of pregnant women in England have chronic hepatitis B virus (HBV) infection and need services to prevent vertical transmission. In this national audit, sociodemographic, clinical and laboratory information was requested from all maternity units in England for hepatitis B surface antigen-positive women initiating antenatal care in 2014. We describe these women's characteristics and indicators of access to/uptake of healthcare. Of 2542 pregnancies in 2538 women, median maternal age was 31 [IQR 27, 35] years, 94% (1986/2109) were non-UK born (25% (228/923) having arrived into the UK <2 years previously) and 32% (794/2473) had ⩾2 previous live births. In 39%, English levels were basic/less than basic. Antenatal care was initiated at median 11.3 [IQR 9.6, 14] gestation weeks, and 'late' (⩾20 weeks) in 10% (251/2491). In 70% (1783/2533) of pregnancies, HBV had been previously diagnosed and 11.8% (288/2450) had ⩾1 marker of higher infectivity. Missed specialist appointments were reported in 18% (426/2339). Late antenatal care and/or missed specialist appointments were more common in pregnancies among women lacking basic English, arriving in the UK ⩽2 years previously, newly HBV diagnosed, aged <25 years and/or with ⩾2 previous live births. We show overlapping groups of pregnant women with chronic HBV vulnerable to delayed or incomplete care.

Keywords: Antenatal care; England; hepatitis B virus; migrant health; pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • England / epidemiology
  • Female
  • Hepatitis B Surface Antigens
  • Hepatitis B virus
  • Hepatitis B* / diagnosis
  • Hepatitis B* / epidemiology
  • Hepatitis B, Chronic* / epidemiology
  • Hepatitis B, Chronic* / prevention & control
  • Humans
  • Infectious Disease Transmission, Vertical / prevention & control
  • Pregnancy
  • Pregnancy Complications, Infectious* / epidemiology
  • Pregnant Women
  • Prenatal Care

Substances

  • Hepatitis B Surface Antigens