Respiratory inductive plethysmography (RIP) is a method that can be used to assess breathing patterns in infants without an airway connection. Ribcage and abdomen transducers are used which require gain factor calculation for calibration. We employed a single position graphic (SPG) calibration technique for gain factor calculation in RIP to obtain breathing pattern data for 70 infants in the quietly awake state. The SPG technique utilizes selection of two breaths from a 20s run of breaths with different ribcage/pneumotachograph (RC/PNT) and abdomen/pneumotachograph (AB/PNT) ratios for the gain factor calculation. Validation of gain factors was performed by comparing volumes obtained simultaneously by RIP and PNT. In 46 of the infants, maintenance of gain factor accuracy was confirmed following position reversal. Revalidation after position change could not be accomplished in 24 infants who were aroused into an agitated state. Breathing patterns were collected by RIP alone on the 46 infants who remained accurately calibrated in the supine and prone positions. No significant correlations were found between breathing pattern data and anthropometric characteristics. When the infants were repositioned, no consistent pattern of change could be identified. This study suggests that the SPG technique provides time-efficient and accurate calibration of RIP in the newborn infant. Furthermore, accuracy is maintained through position change if the infant remains in the same behavioral state. Breathing pattern data presented is representative of normative values in the quietly awake state for our study population.