I kappa B kinase interacting protein as a promising biomarker in pan-cancer: A multi-omics analysis

Chenyang Bi; Zhe Wang; Yafei Xiao; Ying Zhao; Runjiang Guo; Luyao Xiong; Zhiyu Ji; Yifan Li; Quanying Li; Changjiang Qin

doi:10.3389/fgene.2023.1138137

I kappa B kinase interacting protein as a promising biomarker in pan-cancer: A multi-omics analysis

Front Genet. 2023 Mar 14:14:1138137. doi: 10.3389/fgene.2023.1138137. eCollection 2023.

Authors

Chenyang Bi¹, Zhe Wang¹, Yafei Xiao¹, Ying Zhao¹, Runjiang Guo¹, Luyao Xiong¹, Zhiyu Ji¹, Yifan Li¹, Quanying Li¹, Changjiang Qin¹

Affiliation

¹ Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China.

Abstract

Background: Human chromosome 12 contains I kappa B kinase interacting protein (IKBIP) is also commonly known as IKIP. The involvement of IKBIP in the growth of tumors has only been discussed in a small number of publications. Purpose: To explore the role that IKBIP plays in the development of a wide variety of neoplasms, as well as the tumor immunological microenvironment. Methods: UALCAN, HPA, Genotype Tissue Expression, Cancer Genome Maps, and other datasets were used to analyze IKBIP expression. We thoroughly investigated the predictive importance of IKBIP in pan-cancer, clinical traits, and genetic anomalies. We studied whether there is a link between IKBIP and immune-related genes, microsatellite instability (MSI), and the incidence of tumor mutational burden (TMB). The link between immune cell infiltration and IKBIP expression was examined using data on immune cell infiltration from ImmuCellAI, TIMER2, and earlier studies. Finally, gene set enrichment analysis (GSEA) was performed to determine the signaling pathways associated with IKBIP. Results: IKBIP is highly expressed in most cancers and is negatively associated with the prognosis of several major cancer types. Furthermore, IKBIP expression was linked to TMB in 13 cancers and MSI in seven cancers. Additionally, IKBIP is associated with numerous immunological and cancer-promoting pathways. Simultaneously, various cancer types have unique tumor-infiltrating immune cell profiles. Conclusion: IKBIP has the potential to act as a pan-cancer oncogene and is crucial for both carcinogenesis and cancer immunity. Elevated IKBIP expression implies an immunosuppressive environment and may be used as a prognostic biomarker and therapeutic target.

Keywords: IKBIP; immunosuppressive microenvironment; methylation; pan-cancer; prognostic biomarker.

Grants and funding

This study was supported by Science and Technology Foundation of Henan Province (172102310152), Natural Science Foundation of Henan Province (182300410359), Science and Technology Foundation of Henan Province (SBGJ202002097), Science and Technology Foundation of Henan Province (192102310099), Henan Provincial Education Fund (19A320020), Postgraduate Cultivating Innovation and Quality Improvement Action Plan of Henan University (SYLYC2022141 and SYLJD2022009). Henan Province United Common Project Fund (LHGJ20220663), Henan Provincial Science and Technology Research Project (222102310134) and Ruida Pharmaceutical Clinical Medicine Postgraduate Education Innovation Training Base Project of Henan University.