Coccidioidomycosis in Joint Replacement: A Review of the Literature With Case Presentations

Francesca Anna Giordani; Brendan Kiernan; Mauro Giordani; Morgan Darrow; Steven Thorpe; John P Meehan

doi:10.1016/j.artd.2023.101123

Coccidioidomycosis in Joint Replacement: A Review of the Literature With Case Presentations

Arthroplast Today. 2023 Mar 28:21:101123. doi: 10.1016/j.artd.2023.101123. eCollection 2023 Jun.

Authors

Francesca Anna Giordani¹, Brendan Kiernan¹, Mauro Giordani¹, Morgan Darrow¹, Steven Thorpe¹, John P Meehan¹

Affiliation

¹ Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, CA, USA.

Abstract

Coccidioidomycosis is a fungal infection endemic to certain regions of the Americas. In some cases, the organism may infect the musculoskeletal system, resulting in a prosthetic joint infection (PJI). Due to its difficulty in diagnosis, treatment of coccidioidomycosis in PJI is often delayed. Furthermore, with limited number of case reports, a standard of care in treatment has yet to be established. We present 2 cases of coccidioidomycosis PJI, the extensive evaluation that led to the diagnosis, and the treatment provided. This report highlights the natural progression of coccidioidomycosis in a prosthetic joint, the diagnostic features including histology, advanced imaging, and final treatment administered.

Keywords: Coccidiomycosis; Fungal; Hip replacement; Knee replacement; Prosthetic joint infection.

Publication types

Case Reports