Intracellular persister: A stealth agent recalcitrant to antibiotics

Nicolas Personnic; Patricia Doublet; Sophie Jarraud

doi:10.3389/fcimb.2023.1141868

Intracellular persister: A stealth agent recalcitrant to antibiotics

Front Cell Infect Microbiol. 2023 Mar 31:13:1141868. doi: 10.3389/fcimb.2023.1141868. eCollection 2023.

Authors

Nicolas Personnic^{1

2}, Patricia Doublet^{1

3}, Sophie Jarraud^{1

3

4}

Affiliations

¹ CIRI, Centre International de Recherche en Infectiologie, CNRS UMR 5308, INSERM U1111, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
² Group Persistence and Single-Cell Dynamics of Respiratory Pathogens, Lyon, France.
³ Group Legionella Pathogenesis, Lyon, France.
⁴ National Reference Centre for Legionella, Institute of Infectious Agents, Hospices Civils de Lyon, Lyon, France.

Abstract

The bulk of bacteria transiently evading appropriate antibiotic regimes and recovered from non-resolutive infections are commonly refer to as persisters. In this mini-review, we discuss how antibiotic persisters stem from the interplay between the pathogen and the cellular defenses mechanisms and its underlying heterogeneity.

Keywords: antibiotic; heterogeneity; infection; persisters; virulence.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / pharmacology
Anti-Bacterial Agents* / therapeutic use
Bacteria*

Substances

Anti-Bacterial Agents

Grants and funding

Research at the CIRI is supported by the Inserm, CNRS, University Lyon 1, and ENS Lyon. NP is a CNRS senior scientist. NP was the recipient of an SNF Ambizione fellowship (PZ00P3_161492, PZ00P3_185529). The research in the laboratory of N.P. is supported by a CIRI seed funding and the ANR. PD is Professor at the University Lyon 1. The research in the laboratory of PD is supported by Inserm, CNRS, University Lyon 1 and the ANR. SJ is Professor at University Lyon 1 and hospital practitioner in microbiology at Hospices Civils de Lyon. The activities at the NRCL is supported by Santé Public France. The funders had no role in study design, decision to publish, or preparation of the manuscript.