From Translation to Treatment

Xuemin Wang; Christopher G Proud

doi:10.12703/r/12-9

From Translation to Treatment

Fac Rev. 2023 Apr 28:12:9. doi: 10.12703/r/12-9. eCollection 2023.

Authors

Xuemin Wang¹, Christopher G Proud¹

Affiliation

¹ Lifelong Health, South Australian Health & Medical Research Institute, Adelaide SA5000, Australia.

Abstract

Protein synthesis (mRNA translation) plays a crucial role in cell function by shaping the proteome -making all the proteins each cell requires at the right time and in the right quantities and places. Proteins carry out almost every job in the cell. Protein synthesis is also a major component of the cellular economy, using large amounts of metabolic energy and resources, especially amino acids. Accordingly, it is tightly regulated through diverse mechanisms which respond, for example, to nutrients, growth factors, hormones, neurotransmitters and stressful situations.

Keywords: MNK; VWM; eIF2B; eIF4E; mTORC1.

Publication types

Review