Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Ann Rheum Dis. 2023 Aug;82(8):1117-1120. doi: 10.1136/ard-2023-223952. Epub 2023 May 5.

Christina Bergmann^{1

2}, Fabian Müller^{2

3}, Jörg H W Distler^{1

2

4

5}, Andrea-Hermina Györfi^{4

5}, Simon Völkl^{2

3}, Michael Aigner^{2

3}, Sascha Kretschmann^{2

3}, Hannah Reimann^{2

3}, Thomas Harrer^{1

2}, Nadine Bayerl⁶, Sebastian Boeltz^{1

2}, Andreas Wirsching^{1

2}, Jule Taubmann^{1

2}, Wolf Rösler^{2

3}, Bernd Spriewald^{2

3}, Jochen Wacker^{1

2}, Armin Atzinger⁷, Michael Uder⁶, Torsten Kuwert⁷, Andreas Mackensen^{2

3}, Georg Schett^{8

2}

¹ Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
² Deutsches Zentrum Immuntherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
³ Department of Internal Medicine 5-Haematology and Clinical Oncology, FAU Erlangen-Nurnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
⁴ Department of Rheumatology, Universitatsklinikum Dusseldorf, Dusseldorf, Germany.
⁵ Hiller Research Unit, University of Düsseldorf, Duesseldorf, Germany.
⁶ Institute of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
⁷ Institute of Nuclear Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
⁸ Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany georg.schett@uk-erlangen.de.

No abstract available

Keywords: B-Lymphocytes; Systemic Sclerosis; Treatment.

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