Macrophage Nrf 2 the rescue

J Cell Biol. 2023 Jun 5;222(6):e202305036. doi: 10.1083/jcb.202305036. Epub 2023 May 22.

Abstract

The exuberant phagocytosis of apoptotic cell corpses by macrophages in Drosophila embryos creates highly oxidative environments. Stow and Sweet discuss work from Clemente and Weavers (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202203062) showing for the first time how macrophage Nrf2 is primed to help sustain immune function and mitigate bystander oxidative damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Drosophila / embryology
  • Drosophila Proteins* / metabolism
  • Macrophages*
  • NF-E2-Related Factor 2* / metabolism
  • Oxidative Stress
  • Phagocytosis*

Substances

  • Drosophila Proteins
  • NF-E2-Related Factor 2
  • Keap1 protein, Drosophila