Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Yifei Zou; Henghe Shi; Ning Liu; He Wang; Xianjing Song; Bin Liu

doi:10.3389/fcvm.2023.1195464

Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Front Cardiovasc Med. 2023 May 12:10:1195464. doi: 10.3389/fcvm.2023.1195464. eCollection 2023.

Authors

Yifei Zou¹, Henghe Shi¹, Ning Liu¹, He Wang¹, Xianjing Song¹, Bin Liu¹

Affiliation

¹ Department of Cardiology, The Second Hospital of Jilin University, Changchun, China.

Abstract

Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a variety of cellular stress states. It is involved in regulating proteostasis and protecting cells from multiple sources of stress injury by stabilizing protein conformation and promoting the refolding of misfolded proteins. Previous studies have confirmed that HSP27 is involved in the development of cardiovascular diseases and plays an important regulatory role in this process. Herein, we comprehensively and systematically summarize the involvement of HSP27 and its phosphorylated form in pathophysiological processes, including oxidative stress, inflammatory responses, and apoptosis, and further explore the potential mechanisms and possible roles of HSP27 in the diagnosis and treatment of cardiovascular diseases. Targeting HSP27 is a promising future strategy for the treatment of cardiovascular diseases.

Keywords: cardiovascular diseases; cardiovascular pathophysiology; heat shock protein 27; phosphorylation; therapy.

Publication types

Review

Grants and funding

This work was supported by the Jilin Provincial Department of Science and Technology (grant numbers 20220303002SF); Jilin Provincial Health Care Commission (grant numbers 2021LC016); and Jilin Provincial Development and Reform Commission (grant numbers 2022C003).