MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury

Chaonan Zhang; Cheng Wei; Xingqi Huang; Changxin Hou; Chuan Liu; Shu Zhang; Zilong Zhao; Yafan Liu; Ruiguang Zhang; Lei Zhou; Ying Li; Xubo Yuan; Jianning Zhang

doi:10.1186/s12916-023-02895-7

MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury

BMC Med. 2023 May 30;21(1):199. doi: 10.1186/s12916-023-02895-7.

Authors

Chaonan Zhang^#¹, Cheng Wei^#¹, Xingqi Huang^#¹, Changxin Hou², Chuan Liu¹, Shu Zhang¹, Zilong Zhao¹, Yafan Liu¹, Ruiguang Zhang¹, Lei Zhou¹, Ying Li¹, Xubo Yuan³, Jianning Zhang⁴

Affiliations

¹ Key Laboratory of Post-Neurotrauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Department of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
² Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China.
³ Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China. xbyuan@tju.edu.cn.
⁴ Key Laboratory of Post-Neurotrauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Department of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. jianningzhang@hotmail.com.

^# Contributed equally.

Abstract

Background: Contact sports athletes and military personnel who suffered a repetitive mild traumatic brain injury (rmTBI) are at high risk of neurodegenerative diseases such as advanced dementia and chronic traumatic encephalopathy (CTE). However, due to the lack of specific biological indicators in clinical practice, the diagnosis and treatment of rmTBI are quite limited.

Methods: We used 2-methacryloyloxyethyl phosphorylcholine (MPC)-nanocapsules to deliver immunoglobulins (IgG), which can increase the delivery efficiency and specific target of IgG while reducing the effective therapeutic dose of the drug.

Results: Our results demonstrated that MPC-capsuled immunoglobulins (MPC-n (IgG)) significantly alleviated cognitive impairment, hippocampal atrophy, p-Tau deposition, and myelin injury in rmTBI mice compared with free IgG. Furthermore, MPC-n (IgG) can also effectively inhibit the activation of microglia and the release of inflammatory factors.

Conclusions: In the present study, we put forward an efficient strategy for the treatment of rmTBI-related cognitive impairment and provide evidence for the administration of low-dose IgG.

Keywords: Cognitive impairment; Immunoglobulin; Neuro-inflammation; Repetitive mild traumatic brain injury.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain
Brain Concussion* / complications
Brain Concussion* / drug therapy
Brain Concussion* / psychology
Cognitive Dysfunction* / drug therapy
Disease Models, Animal
Immunoglobulin G
Mice
Neurodegenerative Diseases*

Substances

Immunoglobulin G