Extracellular vesicles in tumorigenesis, metastasis, chemotherapy resistance and intercellular communication in osteosarcoma

Yi Liao; Qian Yi; Jinglong He; Dixi Huang; Jianyi Xiong; Wei Sun; Weichao Sun

doi:10.1080/21655979.2022.2161711

Extracellular vesicles in tumorigenesis, metastasis, chemotherapy resistance and intercellular communication in osteosarcoma

Bioengineered. 2023 Dec;14(1):113-128. doi: 10.1080/21655979.2022.2161711.

Authors

Yi Liao¹, Qian Yi^{2

3}, Jinglong He⁴, Dixi Huang⁵, Jianyi Xiong⁴, Wei Sun⁴, Weichao Sun⁴

Affiliations

¹ Department of Thoracic Surgery, Southwest Hospital, Army Medical University, Chongqing, Chongqing, China.
² Department of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan, China.
³ The Central Laboratory, Affiliated Hospital of Putian University, Putian, Fujian, China.
⁴ Department of Orthopaedics, Shenzhen Second People's Hospital (The First Affiliated Hospital of Shenzhen University), Shenzhen, China.
⁵ Guangzhou Medical University, Guangzhou, China.

Abstract

Extracellular vehicles play crucial function in osteosarcoma tumorigenesis.Extracellular vehicles mediated the intercellular communication of osteosarcoma cells with other types cells in tumor microenvironment.Extracellular vehicles have potential utility in osteosarcoma diagnosis and treatment.

Keywords: Osteosarcoma; drug resistance; extracellular vesicles; metastasis; therapeutics; tumor microenvironment.

Publication types

Review

MeSH terms

Bone Neoplasms* / pathology
Carcinogenesis / pathology
Cell Communication
Cell Transformation, Neoplastic / pathology
Extracellular Vesicles*
Humans
Osteosarcoma* / pathology
Tumor Microenvironment

Grants and funding

This work was supported by funds from the General Project of Chongqing Natural Science Foundation (No. cstc2021jcyj-msxmX0642 to Yi Liao), the National Natural Sciences Foundation of China (No.82003126 and No. 82172831 to Weichao Sun and Yi Liao, respectively)，and the Shenzhen Science and Technology Projects (No. JCYJ20190807102601647 and JCYJ20210324103604013 to Weichao Sun and to Qian Yi, respectively).