The recombinome of IKZF1 deletions in B-cell precursor ALL

Bruno A Lopes; Claus Meyer; Heloysa Bouzada; Marius Külp; Ana Luiza Tardem Maciel; Patrizia Larghero; Thayana C Barbosa; Caroline P Poubel; Caroline Barbieri; Nicola C Venn; Luciano Dalla Pozza; Draga Barbaric; Chiara Palmi; Grazia Fazio; Claudia Saitta; Thais F Aguiar; Mecneide M Lins; Maura R V Ikoma-Colturato; Marcia Schramm; Eduardo Chapchap; Gianni Cazzaniga; Rosemary Sutton; Rolf Marschalek; Mariana Emerenciano

doi:10.1038/s41375-023-01935-8

The recombinome of IKZF1 deletions in B-cell precursor ALL

Leukemia. 2023 Aug;37(8):1727-1731. doi: 10.1038/s41375-023-01935-8. Epub 2023 Jun 29.

Authors

Bruno A Lopes^{1

2}, Claus Meyer³, Heloysa Bouzada⁴, Marius Külp³, Ana Luiza Tardem Maciel⁴, Patrizia Larghero³, Thayana C Barbosa⁴, Caroline P Poubel⁴, Caroline Barbieri⁴, Nicola C Venn⁵, Luciano Dalla Pozza⁶, Draga Barbaric⁷, Chiara Palmi⁸, Grazia Fazio⁸, Claudia Saitta⁸, Thais F Aguiar⁹, Mecneide M Lins¹⁰, Maura R V Ikoma-Colturato¹¹, Marcia Schramm^{12

13}, Eduardo Chapchap¹⁴, Gianni Cazzaniga^{8

15}, Rosemary Sutton⁵, Rolf Marschalek³, Mariana Emerenciano¹⁶

Affiliations

¹ Program of Molecular Carcinogenesis and Division of Clinical Research, Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, Brazil. blopes@inca.gov.br.
² DCAL, Institute of Pharmaceutical Biology, Goethe-University, Frankfurt/Main, Germany. blopes@inca.gov.br.
³ DCAL, Institute of Pharmaceutical Biology, Goethe-University, Frankfurt/Main, Germany.
⁴ Program of Molecular Carcinogenesis and Division of Clinical Research, Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, Brazil.
⁵ Molecular Diagnostics, Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
⁶ Cancer Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia.
⁷ Sydney Children's Hospital, Randwick, NSW, Australia.
⁸ Tettamanti Cente, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
⁹ Arthur Siqueira Cavalcanti Hematology Institute (HEMORIO), Rio de Janeiro, Brazil.
¹⁰ Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.
¹¹ Hospital Amaral Carvalho, São Paulo, Brazil.
¹² Prontobaby Hospital da Criança, Rio de Janeiro, Brazil.
¹³ Serviço de Hematologia, Hospital do Câncer I, INCA, Rio de Janeiro, Brazil.
¹⁴ Hospital Israelita Albert Einstein, São Paulo, Brazil.
¹⁵ Medical Genetics, School of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.
¹⁶ Program of Molecular Carcinogenesis and Division of Clinical Research, Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA), Rio de Janeiro, Brazil. memerenciano@inca.gov.br.

PMID: 37386080
DOI: 10.1038/s41375-023-01935-8

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Letter

MeSH terms

Gene Deletion
Humans
Ikaros Transcription Factor / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Prognosis
Transcription Factors*

Substances

Transcription Factors
Ikaros Transcription Factor
IKZF1 protein, human