New Insight Into Cardioprotection From Anthracyclines: Still Converging on the Mitochondria

Qun Chen; Giselle C Meléndez; Edward J Lesnefsky

doi:10.1016/j.jaccao.2023.01.008

New Insight Into Cardioprotection From Anthracyclines: Still Converging on the Mitochondria

JACC CardioOncol. 2023 Jun 20;5(3):374-376. doi: 10.1016/j.jaccao.2023.01.008. eCollection 2023 Jun.

Authors

Qun Chen¹, Giselle C Meléndez^{2

3}, Edward J Lesnefsky^{1

4

5

6}

Affiliations

¹ Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
² Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
³ Section on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
⁴ Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA.
⁵ Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, USA.
⁶ Medical Service of the McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.

No abstract available

Keywords: cardiotoxicity; cyclin-dependent kinase 2 (CDK2); doxorubicin; reactive oxygen species; retinoblastoma-like peptide 2 (RBL2); topoisomerase 2.

Publication types

Editorial

Grants and funding

I01 BX001355/BX/BLRD VA/United States