KRAS regulation of miRNA: Stepping on the brake to go faster

Clint A Stalnecker; Channing J Der

doi:10.1016/j.molcel.2023.06.029

KRAS regulation of miRNA: Stepping on the brake to go faster

Mol Cell. 2023 Jul 20;83(14):2390-2392. doi: 10.1016/j.molcel.2023.06.029.

Authors

Clint A Stalnecker¹, Channing J Der²

Affiliations

¹ University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA. Electronic address: clints@email.unc.edu.
² University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA. Electronic address: cjder@med.unc.edu.

PMID: 37478822
DOI: 10.1016/j.molcel.2023.06.029

Abstract

In this issue of Molecular Cell, Shui et al.¹ use a systems biology approach to unravel a paradoxical role of microRNA in oncogenic Kras^G12D regulation of gene and protein expression.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Genes, ras
MicroRNAs* / genetics
Mutation
Proto-Oncogene Proteins p21(ras) / genetics

Substances

MicroRNAs
Proto-Oncogene Proteins p21(ras)

Abstract

Publication types

MeSH terms

Substances

Grants and funding