SIRT1 and SIRT6: The role in aging-related diseases

Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166815. doi: 10.1016/j.bbadis.2023.166815. Epub 2023 Jul 26.

Abstract

Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1-7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels. We also discuss the therapeutic potential of SIRT1 and SIRT6 modulators in the treatment of these diseases and challenges thereof.

Keywords: Aging; Aging-related diseases; SIRT1; SIRT6; Sirtuins.

Publication types

  • Review

MeSH terms

  • Aging* / genetics
  • Aging* / metabolism
  • Animals
  • Energy Metabolism
  • Humans
  • Inflammation
  • Sirtuin 1* / genetics
  • Sirtuin 1* / metabolism
  • Sirtuins* / genetics
  • Sirtuins* / metabolism

Substances

  • SIRT1 protein, human
  • SIRT6 protein, human
  • Sirtuin 1
  • Sirtuins