Effect and possible mechanisms of saponins in Chinese herbal medicine exerts for the treatment of myocardial ischemia-reperfusion injury in experimental animal: a systematic review and meta-analysis

Jiahao Sun; Jiarong Fan; Fan Yang; Xin Su; Xinye Li; Li Tian; Can Liu; Yanwei Xing

doi:10.3389/fcvm.2023.1147740

Effect and possible mechanisms of saponins in Chinese herbal medicine exerts for the treatment of myocardial ischemia-reperfusion injury in experimental animal: a systematic review and meta-analysis

Front Cardiovasc Med. 2023 Jul 26:10:1147740. doi: 10.3389/fcvm.2023.1147740. eCollection 2023.

Authors

Jiahao Sun^#¹, Jiarong Fan^#², Fan Yang^#³, Xin Su^#⁴, Xinye Li², Li Tian², Can Liu³, Yanwei Xing³

Affiliations

¹ Yanqing Hospital of Beijing Chinese Medicine Hospital, Beijing, China.
² Clinical Department of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
³ Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
⁴ Sun Yat-sen University Cancer Center, Guangzhou, China.

^# Contributed equally.

Abstract

Introduction: Preventing ischemia-reperfusion injury is the main direction of myocardial infarction treatment in the convalescent stage. Some studies have suggested that saponins in Traditional Chinese medicine (TCM) preparations can protect the myocardium by various mechanisms. Our meta-analysis aims to evaluate the efficacy of TCM saponins in treating myocardial ischemia-reperfusion injury (MIRI) and to summarize the potential molecular mechanisms further.

Methods: We conducted a literature search in six electronic databases [Web of Science, PubMed, Embase, Cochrane Library, Sinomed, China National Knowledge Infrastructure (CNKI)] until October 2022.

Results: Seventeen eligible studies included 386 animals (254 received saponins and 132 received vehicles). The random effect model is used to calculate the combined effect. The effect size is expressed as the weighted average difference (WMD) and 95% confidence interval (CI). Compared with placebo, saponins preconditioning reduced infarct size after MIRI significantly (WMD: -3.60,95% CI: -4.45 to -2.74, P < 0.01, I²: 84.7%, P < 0.001), and significantly increased EF (WMD: 3.119, 95% CI: 2.165 to 4.082, P < 0.01, I²: 82.9%, P < 0.0 L) and FS (WMD: 3.157, 95% CI: 2.218 to 4.097, P < 0.001, I²: 81.3%, P < 0.001).

Discussion: The results show that the pre-administration of saponins from TCM has a significant protective effect on MIRI in preclinical studies, which provides an application prospect for developing anti-MIRI drugs with high efficiency and low toxicity.

Keywords: cardiac function; experimental animal model; infarct size; meta-analysis; myocardial ischemia-reperfusion injury; saponins; traditional Chinese medicine.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81725024 and 81430098), the CACMS Innovation Fund (Grant No. CI2021A00919), and the National Key R&D Program of China (Grant Nos. 2018YFC1704901 and 2018YFC1704900).