A novel sample storage system involves the storage of frozen sera and other fluids within small heat-sealed segments of Tygon tubing. Each series of attached segments comprises one sample divided into small aliquots and protected by a cellulose acetate butyrate tube situated in a specially constructed rack in a low-temperature freezer. This storage system offers several benefits including elimination of repeated freezing and thawing, protection against contamination of bulk samples, simplicity in keeping inventory records, ease of retrieving samples, and elimination of the need to return samples to storage. It is efficient, economical and applicable to a variety of liquid specimens, and greatly increases the length of potential storage life.