Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis

Menglong Shi; Tianye Sun; Zhaochen Ji; Yucong Ma; Min Zhao; Fengwen Yang; Junhua Zhang

doi:10.3389/fphar.2023.1265603

Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis

Front Pharmacol. 2023 Sep 18:14:1265603. doi: 10.3389/fphar.2023.1265603. eCollection 2023.

Authors

Menglong Shi^#^{1

2}, Tianye Sun^#³, Zhaochen Ji^{1

2}, Yucong Ma^{1

2}, Min Zhao⁴, Fengwen Yang^{1

2}, Junhua Zhang^{1

2}

Affiliations

¹ State Key Laboratory of Component-Based Chinese Medicine, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
² Evidence-Based Medicine Center, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
³ Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
⁴ The First Affiliated Hospital of Henan University of CM, Zhengzhou, China.

^# Contributed equally.

Abstract

Background: Coronary heart disease (CHD) poses a serious threat to public health, and the current medical management still faces significant challenges. Reliable evidence on the efficacy of Shuxuening injection (SXNI) in CHD is still lacking, even though it is widely used in China. Purpose: To evaluate the efficacy of SXNI combination therapy in treating CHD. Methods: A systematic search of eight databases was conducted to identify relevant randomized controlled trials (RCTs) from the inception of each database until June 2023. ROB 2.0, RevMan 5.4, and Stata 15.1 were used for quality evaluation and data analysis. The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the quality of evidence. Results: A total of 3,779 participants from 39 studies were included. The results showed SXNI combination therapy increased the clinical efficacy and decreased the frequency and duration of angina. Furthermore, SXNI combination therapy improved cardiac function of patients by decreasing LVEDD, and increased CI, CO, and LVEF. It also improved blood lipid profiles by increasing HDL, decreasing TC, TG, and LDL. The thrombosis factors of patients were also improved by decreasing FIB, PV, HCT, and HS. Moreover, SXNI combination therapy was superior to the conventional treatment in improving CRP levels, increasing ECG efficacy and BNP. However, due to the limited safety information, reliable safety conclusions could not be drawn. Furthermore, the levels of evidence ranged from very low to moderate due to publication bias and heterogeneity. Conclusion: SXNI can effectively improve angina symptoms, clinical efficacy, cardiac function, blood lipid indicators, and thrombosis factors of patients with CHD. However, more multi-center and large-sample studies are needed to confirm the conclusions due to the limitations of this study. Registration https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=399606; Identifier: CRD42023433292.

Keywords: Shuxuening injection; coronary heart disease; meta-analysis; randomized controlled trial; systematic review.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by National Natural Science Foundation of China (82074583), the Methodological Research on Intelligent Transformation of Evidence in Traditional Chinese Medicine (20JCJQJC00120), Strategic Research and Consulting Project of Chinese Academy of Engineering (2023-PP-05), and Tianjin 131 innovative talent training project (RS2101).