The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

Songhua Liu; Yao Rong; Mingzheng Tang; Qiqi Zhao; Chunyan Li; Wenbin Gao; Xiaojun Yang

doi:10.2174/0113862073268591230928100922

The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

Comb Chem High Throughput Screen. 2023 Oct 11. doi: 10.2174/0113862073268591230928100922. Online ahead of print.

Authors

Songhua Liu¹, Yao Rong¹, Mingzheng Tang¹, Qiqi Zhao², Chunyan Li³, Wenbin Gao¹, Xiaojun Yang^{3

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Affiliations

¹ The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou 730000, China.
² College of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, China.
³ The First Clinical Medical School of Lanzhou University, Lanzhou 730000, China.
⁴ Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730000, China.
⁵ Gansu key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology, Gansu Provincial Hospital, Lanzhou 730000, China.
⁶ Gansu Research Center of Prevention and Control Project for Digestive Oncology, Gansu Provincial Hospital, Lanzhou, 730000, China.
⁷ Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment of National Health and Health Commission, Lanzhou, 730000, China.

PMID: 37842903
DOI: 10.2174/0113862073268591230928100922

Abstract

Gastric cancer is one of the most common malignancies worldwide. Despite significant advancements in surgical and adjuvant treatments, patient prognosis remains unsatisfactory. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that lack protein-coding capacity but can participate in various mechanisms of tumor malignancy. Among them, small nucleolar host genes (SNHGs) represent a subgroup of lncRNAs. Studies have revealed their involvement not only in gastric cancer cell proliferation, invasion, migration, epithelialmesenchymal transition (EMT), and apoptosis but also in chemotherapy resistance and tumor stemness. This review comprehensively summarizes the biological functions, molecular mechanisms, and clinical significance of SNHGs in gastric cancer. It provides novel insights into potential biomarkers and therapeutic targets for the exploration of gastric cancer.

Keywords: Gastric cancer; Long non-coding RNA small nucleolar RNA host gene; biological function; molecular mechanisms..