The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity

Xuan Wang; Zecheng Chang; Tingting Zhao; Weiyao Zhong; Jingwei Shi; Guoqing Wang; Xuesong Xu

doi:10.3389/fimmu.2023.1256574

The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity

Front Immunol. 2023 Nov 15:14:1256574. doi: 10.3389/fimmu.2023.1256574. eCollection 2023.

Authors

Xuan Wang^#¹, Zecheng Chang^#¹, Tingting Zhao¹, Weiyao Zhong¹, Jingwei Shi¹, Guoqing Wang¹, Xuesong Xu¹

Affiliation

¹ Key Laboratory of Pathobiology Ministry of Education, College of Basic Medical Sciences/China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.

^# Contributed equally.

Abstract

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability. To combat this, researchers have turned to omics approaches, particularly epitranscriptomics, to limit infection and develop effective therapeutic strategies. Multi-omics can provide the host response dynamics during multiple disease phases to reveal the molecular and cellular landscapes. Epitranscriptomics focuses on the mechanisms of gene transcription in cells and tissues and the relationship between genetic material and epigenetic regulation. This review highlights the role of post-transcriptional regulation in SARS-CoV-2, which affect various processes such as virus infection, replication, immunogenicity, and pathogenicity. The review also explains the formation mechanism of post-transcriptional modifications and how they can be regulated to combat viral infection and pathogenicity.

Keywords: SARS-CoV-2; pathogenicity; post-transcriptional modification; regulation; virus-host interaction.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / genetics
Epigenesis, Genetic
Humans
Pandemics
SARS-CoV-2
Virulence

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This project was supported by Key Research and Development Program of Ministry of Science and Technology (2022YFF1203204); Special Biosafety Research Program of Logistics Support Department of Military Commission (923070201202) and International Joint Research Center for Pathogen and Infection Informatics, Jilin Province (20210504004GH); Jilin University China-Japan Union Hospital-Basic Medical College Joint Project (KYXZ2022JC02).