Research progress of ferroptosis in Parkinson's disease: a bibliometric and visual analysis

Yangguang Lu; Yiqun Chen; Zihan Jiang; Yaoying Ge; Ruotong Yao; Shangze Geng; Jinxiu Zhang; Feng Chen; Yukai Wang; Guangyong Chen; Dehao Yang

doi:10.3389/fnagi.2023.1278323

Research progress of ferroptosis in Parkinson's disease: a bibliometric and visual analysis

Front Aging Neurosci. 2023 Nov 14:15:1278323. doi: 10.3389/fnagi.2023.1278323. eCollection 2023.

Authors

Yangguang Lu^#¹, Yiqun Chen^#¹, Zihan Jiang^#², Yaoying Ge¹, Ruotong Yao¹, Shangze Geng¹, Jinxiu Zhang², Feng Chen², Yukai Wang², Guangyong Chen³, Dehao Yang⁴

Affiliations

¹ The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
² The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
³ Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁴ Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

^# Contributed equally.

Abstract

Background: In recent years, the role of ferroptosis in Parkinson's disease (PD) has become a research hotspot based on evidence of abnormal iron deposition and lipid peroxidation damage in the brains of PD patients. This study aims to examine the relevant research on ferroptosis and PD from a bibliometric perspective.

Methods: Original research and review articles related to ferroptosis and PD were retrieved from the Web of Science Core Collection (WOSCC) database. Statistical analysis and visualization of information including countries, institutions, authors, journals, and keywords of the included studies were conducted using the R software package "bibliometrix."

Results: A total of 414 articles met the inclusion criteria, averaging 37.86 citations per article. From 2012 to 2022, the average annual growth rate of research in this area was 63.44%. The corresponding authors of published articles were mainly affiliated with institutions in China, the United States, and Australia. Shanghai Jiao Tong University in China and the University of Melbourne in Australia emerged as the most active and influential institutions. The journal with the highest H-index and publication output was Free Radical Biology and Medicine. "Ferroptosis," "immunotherapy," "prognosis" and "microenvironment" were identified as high-frequency keywords, indicating current and future research directions in this field.

Conclusion: This bibliometric study provides insights into current research hotspots and emerging trends in the growing field of ferroptosis research related to PD. The high-frequency keywords identified highlight active areas of investigation involving methods, mechanisms, and populations of interest.

Keywords: Parkinson disease; bibliometrics; biomedical research; ferroptosis; iron-dependent cell death.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation of China (No. 82302081) and the Fundamental Research Funds for the Central Universities (No. 226–2023-0067).