Tetrazole analogs of amino acids as constituents of modifiers of carboxypeptidase A catalysis

FEBS Lett. 1987 Feb 9;212(1):83-6. doi: 10.1016/0014-5793(87)81561-2.

Abstract

The action of substrate analogs containing the tetrazolyl group instead of the C-terminal carboxy group on the peptidase activity of carboxypeptidase A is studied. The analogs compete with the substrate for the secondary binding site thus showing activation phenomena.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / pharmacology*
  • Binding Sites
  • Carboxypeptidases / metabolism*
  • Carboxypeptidases A
  • Catalysis
  • Enzyme Activation
  • Kinetics
  • Tetrazoles / pharmacology

Substances

  • Amino Acids
  • Tetrazoles
  • Carboxypeptidases
  • Carboxypeptidases A